Our Body Reset product has a manufacture Month/Year printed on each label. Theoretically, before opening, if our Body Reset homeopathic is kept at room temperature away from EMF (electromagnetic fields) it will last indefinitely. However, once the bottle is opened, it will inevitably be contaminated with saliva, air, etc. At this point, it has an estimated opened-bottle shelf life of 6 months. The homeopathic drops may be kept at room temperature during a round. If you have an open bottle that will not be used for a while, you may want to refrigerate it.